Having witnessed the success of combination therapy in HIV, cancer and heart disease, the time has come for Alzheimer’s disease. At meetings convened by the Alzheimer’s Association and others, a consensus is emerging that the most effective Alzheimer’s treatments may be those that attack the disease on multiple fronts.
Looking back for a moment… In the 1980s, the world faced a new, unknown virus. HIV/AIDS was spreading virtually unchecked, devastating millions of lives and spurring lively scientific debate. Today, an HIV diagnosis is no longer a death sentence. AIDS-related deaths have fallen by 45 percent since their peak in 2005 according to UNAIDS, a United Nations program for global action against the spread of the virus.
As researchers learned more about HIV, they developed new classes of antiviral medications—each attacking the virus in a unique way. Physicians eventually began prescribing two or more of these drugs together and emerging scientific evidence started revealing the most effective combinations. Today, a powerful three-drug antiviral “cocktail” is allowing people with HIV to live long lives.
Advances in understanding the progression of Alzheimer’s point to a number of underlying biological processes involved in the development of the disease. By leveraging this knowledge, we now have a singular opportunity to pioneer new approaches against Alzheimer’s, including combination therapies.